Collagen is an essential building block of the human body, providing structural support and biological signals to connective tissues and organs, and therefore it is a crucial component for tissue regeneration.

To date, collagen has been extracted from animal and human cadaver sources, baring risk of contamination and allergic response and subjected to harsh purification conditions resulting in irreversible modifications impeding its biofunctionality. Yet, the highly complex and stringent post-translational processing of collagen has prevented the development of large-scale recombinant expression systems.

CollPlant is the first company to succeed in developing a plant platform that effectively expresses human collagen.

The production of our recombinant human Type I collagen (rhCollagen) starts in the genetically engineered tobacco plants. The recombinant human protein in the form of “procollagen” is extracted from the leaves of mature plants and further processed to achieve a highly purified rhCollagen that can be used for the production of medical products.

rhCollagen – The gold standard scaffold for tissue regeneration

Our rhCollagen is identical to the type I collagen produced by the human body, making it the ideal building block for regenerative medicine. It has significant advantages over the currently available tissue-derived collagens, including improved biofunctionality, high homogeneity, and reduced risk of immune response.

Plant-derived rhCollagen

Clear advantages over animal-derived collagen

Animal Extracted

Plant Derived

Few cell binding domains due to partially denatured crosslinked collagen

Many cell binding domains enabled by perfect triple helix enhance cellular attachment

Slow cell proliferation and slow tissue repair Foreign body reactions (e.g. granuloma)
Fast cell proliferation and fast tissue repair

Better Bio-Functionality

  • Accelerates human cell proliferation
  • Faster tissue healing

Superior Homogeneity

  • Controlled physical / rheological properties
  • Reproducibility

Improved Safety and Greater Purity

  • Non-immunogenic
  • Non-allergenic
  • No pathogens
  • No foreign body response


rhCollagen can be fabricated in different forms, shapes, and physical properties. Applications include BioInks for 3D bioprinting of organs, tissues and scaffolds as well as products aimed at aesthetic medicine, orthopedics, advanced wound care and others.

We are advancing collaborations with leading companies in the regenerative medicine field, through licensing of our rhCollagen technology platform for the development of ground-breaking products.

® 2020 CollPlant Biotechnologies Ltd. All rights reserved. Version: CPW 02-20