Collink.3DTM 90

What is Collink.3DTM 90?

Collink.3DTM is the first and only plant-based human collagen bioink platform, mass produced at high consistency, enabling perfect mimicry of the native properties of tissues and organs.  
Collink.3DTM 90 is based on recombinant human type I collagen (rhCollagen), that was chemically modified to generate a curable bioink with approximately 90% of the primary amines converted into methacrylamides. The high degree of functionalization results in stiffer gels, with increased mechanical properties.

#Determined using the 2,4,6-trinitrobenzene sulfonic acid (TNBS) assay, relatively to the rhCollagen source.

What is rhCollagen?

Recombinant human collagen extracted from genetically-engineered plants, without any animal-derived substances or reagents.

Why Collink.3DTM?

Animal free
Optimal rheology at room temperature
Supports high viability of different cell types
Biocompatible, non-immunogenic

What are the uses of Collink.3DTM?

Collink.3DTM enables fabrication of 3D constructs with complex architectures, meeting the demand for specific geometric, physical and biological properties. Biofabricated constructs made with Collink.3DTM can be used in a wide range of soft and hard tissue applications, including tissue models for drug discovery and screening, as well as the development and manufacture of tissue and organ transplants.

Owing to its cytocompatibility, Collink.3DTM supports significant high viability of various cell types – fibroblasts, stem cells, induced pluripotent stem cells, endothelial and epithelial cells.

Fluorescent micrographs of 3D cell culture of human fibroblasts within Collink.3DTM 90 hydrogel. Cells are fixated and stained with Hoechst and RFP. All images were taken with a EVOS 7000 microscope. A. Fibroblasts invasion and migration into gel matrices five days after seeding: commercial standard (left) vs. Collink.3DTM 90 (right). B. Fibroblasts embedded in Collink.3DTM 90 spheroid after a week of incubation at 37 °C.

Collink.3DTM chemical, physical and biological characterization

Extensive studies carried out to characterize the chemical, physical and biological characteristics of Collink.3DTM confirmed its identity to human type I collagen and its performance as a bioink. 


Collink3D™: Ready, set, print!

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