Regenerative
Breast Implant
The Future of Breast Aesthetics
and Reconstruction
Regenerative
Breast Implant
The Future of Breast Aesthetics
and Reconstruction
CollPlant is developing regenerative 3D-bioprinted breast implants to offer a transformative alternative to the current reconstructive and aesthetic implants, which are often associated with significant adverse events. Our implants are composed of rhCollagen combined with supportive biomaterials and are engineered to gradually degrade while guiding the regeneration of natural breast tissue.
These innovative implants are being designed to promote natural breast tissue regeneration without triggering an immune response – aimed at offering a potentially transformative alternative for both aesthetic and reconstructive procedures, including post-mastectomy reconstruction for breast cancer patients.
In the U.S. alone, hundreds of thousands of individuals experience complications from conventional breast implants, including autoimmune responses and, in rare cases, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The demand for safer, tissue-integrating alternatives is clear and urgent.
Regenerative Breast Implant - How does it Work?
The implantation process begins with the insertion of a 3D bioprinted scaffold filled with autologous fat, a commonly used approach to enhance breast volume using the patient’s own fat cells. As the scaffold gradually degrades, it is naturally replaced by newly formed tissue, maintaining the desired breast volume and contour.
Implant design using M&S* methodologies
* M&S – Modeling & Simulation
3D printed Breast scaffold:
rhColl-MA based formulation
Printed Implant
Implant fabrication:
The scaffold design is developed using advanced modeling and simulation methodologies. A formulation based on methacrylated rhCollagen is used for implant fabrication on a DLP printer.
Printed implant with autologous fat
Implantation & vascularization
Implant replacement by newly formed tissue
Implantation process:
The implantation process begins with the insertion of a 3D bioprinted scaffold filled with autologous fat, a commonly used approach to enhance breast volume using the patient’s own fat cells. As the scaffold gradually degrades, it is naturally replaced by newly formed tissue, maintaining the desired breast volume and contour
Implant design using M&S* methodologies
* M&S – Modeling & Simulation
3D printed Breast scaffold:
rhColl-MA based formulation
Printed Implant
Implant fabrication:
The scaffold design is developed using advanced modeling and simulation methodologies. A formulation based on methacrylated rhCollagen is used for implant fabrication on a DLP printer.
Printed implant with autologous fat
Implantation & vascularization
Implant replacement by newly formed tissue
Implantation process:
The implantation process begins with the insertion of a 3D bioprinted scaffold filled with autologous fat, a commonly used approach to enhance breast volume using the patient’s own fat cells. As the scaffold gradually degrades, it is naturally replaced by newly formed tissue, maintaining the desired breast volume and contour
Key Features of CollPlant's Regenerative Breast Implants
These next-generation implants are composed of CollPlant’s proprietary type I rhCollagen combined with biocompatible polymers to form a 3D-printed scaffold. This structure is being designed
to provide mechanical support and promotes tissue ingrowth and vascularization followed by gradual degradation and tissue regeneration.
Product Highlights
Smart Design
Composed of fully biocompatible materials, the implant supports natural tissue ingrowth while degrading in synchronization with tissue regeneration, maintaining breast volume and shape.
Scalable Manufacturing
Produced using advanced 3D bioprinting, the implants offer consistent quality and scalability.
Smart Design
Composed of fully biocompatible materials, the implant is being designed to support natural tissue ingrowth while degrading in synchronization with tissue regeneration, maintaining breast volume and shape.
Scalable Manufacturing
Produced using advanced 3D bioprinting, the implants offer consistent quality and scalability.
Natural Tissue Mimicry
Engineered to replicate the softness, elasticity of natural breast tissue, improving patient comfort and aesthetic outcomes.
Physician-Friendly Integration
Designed for seamless incorporation into existing surgical workflows, simplifying the implantation process for clinicians.
Natural Tissue Mimicry
Engineered to replicate the softness, elasticity of natural breast tissue, improving patient comfort and aesthetic outcomes.
Physician-Friendly Integration
Designed for seamless incorporation into existing surgical workflows, simplifying the implantation process for clinicians.
Preclinical Findings*
Preclinical studies have demonstrated the implants’ ability to support significant vascularization, rapid tissue ingrowth, and early-stage biodegradation while maintaining structural integrity.
Note: CollPlant’s regenerative breast implants are currently under development and are not yet commercially available in the U.S. or EU.
* Data on file at CollPlant
Preclinical Findings*
Preclinical studies have demonstrated the implants’ ability to support significant vascularization, rapid tissue ingrowth, and early-stage biodegradation while maintaining structural integrity.
Note: CollPlant’s regenerative breast implants are currently under development and are not yet commercially available in the U.S. or EU.
* Data on file at CollPlant
Note: CollPlant’s regenerative breast implants are currently under development and are not yet commercially available in the U.S. or EU.
* Data on file at CollPlant